Elicio Therapeutics Inc. (NASDAQ: ELTX) has been making significant strides in the growing cancer vaccination industry with its innovative AMP platform. Founded in 2011, the company has completed multiple successful preclinical trials and has been featured in publications like Nature Medicine and Cancer Immunology Research, a journal of the American Association for Cancer Research (AACR). With promising potential treatments in its pipeline, Elicio Therapeutics’ future seems even brighter than the achievements it made in its past.
Elicio Therapeutics is working to re-engineer the body’s immune response to defeat cancer and infectious diseases with potent lymph node-targeted immunotherapies and vaccines. This approach differentiates Elicio from its competitors and could be highly promising for enhancing anti-tumor immune responses and improving therapeutic efficacy. Elicio’s proprietary Amphiphile or “AMP” platform is being used in the development of cancer immunotherapies for patients facing limited treatment options and often poor outcomes.
Key immune cells are located in the lymph nodes – critical sites that are not engaged by conventional immunotherapies. AMP is built for targeted delivery of payloads to the lymph nodes, guiding the payloads into the lymphatics. This approach is intended to harness the natural ability of the lymph nodes to enhance the magnitude, potency and durability of immune responses to drive antitumor activity. Through this platform, Elicio Therapeutics has developed an innovative pipeline of cancer immunotherapies with the potential to address critical unmet needs, with three vaccine candidates currently in its pipeline: ELI-002, ELI-007 and ELI-008.
ELI-002 is Elicio’s lead investigational asset, targeting Kirsten rat sarcoma (KRAS) driven cancers caused by a mutation of the KRAS gene designed to stimulate an immune response against the seven KRAS mutations driving 25% of solid tumors. Early clinical studies have shown encouraging results, with the vaccine eliciting strong T cell responses and reducing tumor biomarkers in patients with pancreatic and colorectal cancers.
The global cancer vaccine market size was estimated at $7.31 billion in 2022, and it’s expected to grow at a compound annual growth rate (CAGR) of 11.04% by 2030. With the rising prevalence of cancer and increased awareness about cancer vaccination, the market is growing amid a rise in government funding and investments. Elicio Therapeutics presented a Trial in Progress poster on the design of the AMPLIFY-7P trial at the ASCO Gastrointestinal Cancers Symposium in San Francisco, California, and the company announced that the first patient had been dosed as part of the randomized phase 2 study of ELI-002 7P.
In conclusion, Elicio Therapeutics is at the forefront of cancer vaccination innovation with its groundbreaking AMP platform and promising pipeline of immunotherapies. The company’s lead investigational asset, ELI-002, has the potential to address critical unmet needs in cancer treatment, and the global cancer vaccine market is poised for significant growth in the coming years.
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