LIXTE Biotechnology Holdings has expanded its collaboration with The University of Texas MD Anderson Cancer Center and pharmaceutical manufacturer GSK on a clinical trial evaluating its proprietary compound LB-100 in combination with GSK’s Dostarlimab for ovarian clear cell cancer treatment. The trial, initiated in January 2024 and led by Amir Jazaeri, MD, at MD Anderson, has added a second site at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University under Emily M. Hinchcliff, MD, MPH, and is expected to double enrollment to 42 patients following completion of its initial 21-patient target.
The company expects data from the initial cohort to be presented in the first half of 2026. LIXTE’s lead compound, LB-100, is part of a pioneering effort in an entirely new field of cancer biology called activation lethality, which represents a new treatment paradigm. The company has demonstrated that LB-100, a first-in-class PP2A inhibitor, is well-tolerated in cancer patients at doses associated with anti-cancer activity.
Based on extensive published preclinical data available at https://www.lixte.com, LB-100 has the potential to significantly enhance chemotherapies and immunotherapies and improve outcomes for cancer patients. LIXTE’s approach is covered by a comprehensive patent portfolio, and proof-of-concept clinical trials are currently in progress for both Ovarian Clear Cell Carcinoma and Metastatic Colon Cancer.
The expansion of this trial represents a significant step in evaluating a novel combination therapy for ovarian clear cell cancer, a challenging subtype of ovarian cancer. The collaboration between academic institutions and pharmaceutical companies highlights the growing importance of partnerships in advancing cancer research and treatment development. Additional information about LIXTE can be found at https://lixte.com/.
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